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Effect of a standard breakfast on digoxin absorption in normal subjects
Author(s) -
Johnson B. F.,
O'Grady J.,
Sabey G. A.,
Bye Carole
Publication year - 1978
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1978233315
Subject(s) - digoxin , ingestion , chemistry , absorption (acoustics) , plasma concentration , endocrinology , medicine , excretion , zoology , biology , materials science , heart failure , composite material
The influence of food on absorption of digoxin was studied in 6 healthy volunteers who received 1.0 mg digoxin as 4 tablets of Lanoxin either after an overnight fast, immediately after a standard breakfast, or 90 min after a standard breakfast. There was no significant difference between the three regimens in terms of area under the plasma concentration‐time curve for 79 hr or in the 10‐day cumulative urinary excretion. The mean peak plasma concentration was higher (p < 0.05) when digoxin was given fasting (4.2 ± 0.46 ng/ml) than immediately after food (2.8 ± 0.24 ng/ml). The mean peak plasma concentration when digoxin was administered 90 min after food (3.3 ± 0.30 ng/ml) was intermediate but not significantly different from either of the other mean peak concentrations. The results demonstrate that ingestion of food decreases rate but not extent of absorption of concurrently administered digoxin.