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Effects of furosemide in the newborn
Author(s) -
Woo Wan-Ching R.,
Dupont Claire,
Collinge Judith,
Aranda Jacob V.
Publication year - 1978
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1978233266
Subject(s) - furosemide , excretion , creatinine , urine , endocrinology , renal function , medicine , chemistry , blood urea nitrogen , diuretic , fractional excretion of sodium
The effects of furosemide on electrolyte and water excretion were determined in 9 neonates with fluid overload states. Hourly measurements of urine volume, serum and urine Na + , K + , Cl − , creatinine, and blood urea nitrogen were done before and after the intravenous or intramuscular injection offurosemide (1 mg/kg). Mean (±SE) birth weight was 2,261.7 ± 284.4 gm; gestational age was 35.1 ± 1.4 wk, postnatal age was 13.8 ± 6.9 days, blood urea nitrogen was 10.0 ± 1.0 mg%, creatinine was 0.7 ± 0.1 mg%, and glomerular filtration rate was 21.9 ± 3.8 ml · min −1 /1.73 m 2 . Compared with the values obtained before the administration of furosemide, there were significant increases in percent fractional Na + excretion, percent fractional Cl − excretion, urine volume (ml · hr −1 ), and free water clearance (ml · hr −1 ), each of which peaked within 1 hr of furosemide administration and were sustained for another hour thereafter. These effects were discernible for about 5 hr and returned to baseline by 6 hr after administration of the drug. A 2.5‐fold increase in K + excretion (µEq · hr −1 ) was noted I hr after furosemide; this increase was sustained for 2 hr and decreased to the predrug level in 4 hr. Although all infants showed increases in urine volume and electrolyte excretion within 1 hr of furosemide administration, the magnitude of the response exhibited remarkable variability. There is some suggestion that perinatal asphyxia may decrease the response to furosemide.