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Optimal phenytoin therapy: A new technique for individualizing dosage
Author(s) -
Mullen Peter W.
Publication year - 1978
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1978232228
Subject(s) - phenytoin , plot (graphics) , serum concentration , pharmacology , mathematics , medicine , statistics , epilepsy , psychiatry
A simple, new technique (the direct linear plot) for predicting steady‐state serum phenytoin concentrations is described. Although no calculations are required, reliable estimates (comparable with those derived by computer) of the Michaelis‐Menten parameters can be readily determined and used graphically to predict the individualized dose required to achieve a desired serum concentration.