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Dose‐dependent changes in sulfamethazine kinetics in rapid and slow isoniazid acetylators
Author(s) -
Olson William,
Miceli Joseph,
Weber Wendell
Publication year - 1978
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1978232204
Subject(s) - pharmacokinetics , pharmacology , isoniazid , chemistry , clearance , medicine , urology , tuberculosis , pathology
The pharmacokinetics of sulfamethazine (SMZ) was studied in 44 healthy volunteers. After an oral dose of 10 mg/kg we found the usual distribution of rapid and slow acetylators. The differences in the t ½ s between the phenotypes were not due to variations in renal clearance. Repeat studies at this dose showed very little intraindividual variation in t ½ s. After a 40 mg/kg dose there was an increase in the t ½ of SMZ in every subject. The implications of these results on methods of phenotyping are discussed.