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Kinetics of chlormethiazole in patients with alcohol withdrawal manifestations
Author(s) -
Jostell K. G.,
Agurell Stig,
Hollister Leo E.,
Wermuth Bruce
Publication year - 1978
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1978232181
Subject(s) - pharmacokinetics , drug , plasma concentration , alcohol , medicine , oral dose , anesthesia , pharmacology , chemistry , biochemistry
Chlormethiazole administered orally to patients in mild degrees of alcohol withdrawal was generally rapidly absorbed, showed a rapid distributive phase, and had an elimination phase t ½ of 2.6 to 4.7 hr. The plasma concentrations of drug attained following higher oral doses were greater than is usually the case with augmentation of dose. Intravenously infused chlormethiazole in similar patients produced relatively high plasma concentrations of the drug, with distributive and eliminative t ½ similar to those of oral doses. These pharmacokinetic patterns in alcoholic patients more closely resemble those previously reported for normal young subjects than they do for normal aged subjects.