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Absorption of nicotine from small cigars
Author(s) -
Armitage Alan,
Dollery Colin,
Houseman Terry,
Kohner Eva,
Lewis Peter J.,
Turner David
Publication year - 1978
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1978232143
Subject(s) - nicotine , absorption (acoustics) , smoke , sidestream smoke , inhalation , chemistry , cigarette smoke , toxicology , medicine , anesthesia , materials science , biology , organic chemistry , composite material
The absorption of nicotine from cigars was measured in 7 male subjects who each smoked a single small cigar containing 14 C‐nicotine. The proportion of nicotine in the mainstream smoke delivered to the smoker's mouth was greater than that observed for cigarettes, but the proportion of nicotine in the cigar smoke which was retained by the smoker was about the same. The total dose of nicotine retained varied between 1 and 4.5 mg. Arterial plasma concentrations of nicotine were as high as those achieved by cigarette smoking but rose more slowly. Some nicotine from small cigars is absorbed by inhalation of the smoke into the lungs and some by buccal absorption.