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Hemodynamic effects of trimazosin in patients with left ventricular failure
Author(s) -
Franciosa Joseph A.,
Cohn Jay N.
Publication year - 1978
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt197823111
Subject(s) - medicine , heart failure , cardiology , hemodynamics , cardiac index , vascular resistance , vasodilation , pulmonary wedge pressure , cardiac output , central venous pressure , heart rate , blood pressure , anesthesia
Trimazosin is a new quinazoline derivative vasodilator previously thought to act primarily on resistance vessels. Vasodilators characteristically improve hemodynamics in patients with left ventricular failure. Trimazosin in single oral doses of 100 to 300 mg was given to 6 patients with class III–IV congestive heart failure due to ischemic or primary cardiomyopathy and hemodynamics were monitored for 4 hr. Onset of action was apparent at 1 hr, with peak effects occurring at 1 to 3 hr and significant effects persisting at 4 hr. At peak, mean systemic arterial pressurefell from 91.2 ± 4.8 (SEM) to 82.5 ± 2.5 mm Hg (p < 0.05), heart rate was unchanged, and cardiac index (by dye dilution] was up to 2.12 ± 0.27 from 1.76 ± 0.33 L/min/m 2 (NS). Right heart pressures (by Swan‐Ganz catheterization) were reduced, right atrial, 11.3 ± 2.1 to 8.7 ± 1.6 mm Hg (p < 0.02), mean pulmonary arterial pressure, 40.7 ± 4.6 to 33.8 ± 4.8 mm Hg (p < 0.01), and pulmonary arterial wedge, 30.7 ± 4.5 to 23.8 ± 5.0 mm Hg (p < 0.01). Forearm venous capacitance, by occlusion plethysmography, increased from 0.83 ± 0.18 ml/100 gm to 1.12 ± 0.22 ml/100 gm after trimazosin (p < 0.01). Trimazosin is an orally effective vasodilator that acts on both resistance and capacitance vessels in patients with congestive heart failure.