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Propranolol serum levels during twenty‐four hours
Author(s) -
Vervloet E.,
Pluym B. F. M.,
Cilissen J.,
Kahlen K.,
Merkus F. W. H. M.
Publication year - 1977
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1977226853
Subject(s) - propranolol , medicine , blood pressure , body weight , angina , serum concentration , oral administration , anesthesia , endocrinology , myocardial infarction
Propranolol serum levels during a 24‐hr period were determined every 2 hr in 9 hospitalized patients with angina pectoris after oral administration of 40 mg of propranolol 3 times a day. After the first, second, and third tablets the mean maximum serum propranolol concentrations averaged 118 ± 71 ng Iml, 134 ± 97 ng/ml, and 118 ± 94 ng/ml and the mean minimum concentrations averaged 21 ± 18 nglml, 45 ± 25 ng/ml, and 54 ± 34 nglml (±SD), respectively. These data show a very wide inter‐ and intraindividual variation in serum propranolol levels. No relationship was found between serum level and blood pressure or dose (related to body weight).