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Uricosuric effects of niridazole
Author(s) -
Weintraub Michael,
Nash Theodore E.,
Ottesen Eric,
Becker Michael A.
Publication year - 1977
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1977225part1568
Subject(s) - uricosuric , niridazole , uric acid , creatinine , excretion , medicine , chemistry , urinary system , urine , endocrinology , hyperuricemia , schistosomiasis , immunology , helminths
Niridazole, an antischistosomal drug, caused a 44% decrease in the serum uric acid (SUA) concentration in II patients with schistosomiasis. The mean SUA (±SE) was 6.3 ± 1.4 mglIOO ml at baseline and 3.5 ± 1.5 mglIOO ml (p < 0.01) on day 7 of treatment. There was a significant increase in the urinary uric acid/creatinine ratio, from 0.446 ± 0.165 at baseline to 0.550 ± 0.145 on day 3. There was no significant difference on day 7. The fractional clearance of uric acid rose from 7.2 ± 6.8% to 13.9 ± 17.3% (p < 0.01), indicating a uricosuric effect. Oxypurine excretion was unchanged. In a separate study on 7 other patients, the SUA remained low for 4 to 7 days after the last dose. Niridazole, although not an organic acid, has uricosuric effects.