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Effects of urine acidification on plasma and urine phencyclidine levels in overdosage
Author(s) -
Domino Edward F.,
Wilson Ann E.
Publication year - 1977
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1977224421
Subject(s) - urine , phencyclidine , chemistry , urinary system , chromatography , pharmacology , endocrinology , medicine , biochemistry , nmda receptor , receptor
A gas chromatography‐mass Jragmentography‐electron impact (GC‐MS‐EI) assay of phencyclidine (PCP) was adapted for human plasma and urine. This assay is specific for PCP and very sensitive (approximately I ng/ml). Patients with the putative diagnosis of PCP overdosage were studied to correlate plasma and urinary levels with clinical state. Urinary PCP levels were enhanced in an acid urine, which suggests that acidification of the urine is an adjunct in the therapy of PCP overdosage.