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Pharmacokinetics of bendroflumethiazide
Author(s) -
Beermann Bjorn,
Grind Margaretha Groschinsky,
Lindstrom Bjorn
Publication year - 1977
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1977224385
Subject(s) - pharmacokinetics , diuretic , volume of distribution , thiazide , urine , chemistry , plasma concentration , metabolic clearance rate , distribution volume , pharmacology , urinary system , chromatography , medicine , endocrinology
Bendrojlumethiazide (bft) , 10 mg, was administered orally to 9 healthy volunteers. The concentrations of the diuretic in plasma and urine were determined by gas‐liquid chromatography (GLC). Peak plasma levels (86 ± 18 ng/ml) of bft were reached at 2 ± 0.4 hr. The concentration declined with a mean tlh of 3.0 hr. The apparent volume of distribution averaged 1.48 Llkg. The major part of the drug was eliminated via nonrenal mechanisms, the nonrenal clearance being estimated to 269 ± 77 mllmin and renal clearance to 105 ± 24 mllmin. Urinary recovery of the thiazide averaged 30%.