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Effect of antacids on absorption of clorazepate
Author(s) -
Chun A. H. C.,
Carrigan P. J.,
Hoffman D. J.,
Kershner R. P.,
Stuart J. D.
Publication year - 1977
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1977223329
Subject(s) - antacid , oxazepam , absorption (acoustics) , crossover study , chemistry , volunteer , medicine , pharmacokinetics , endocrinology , benzodiazepine , biology , materials science , receptor , alternative medicine , pathology , agronomy , composite material , placebo
The effect of a magnesia and alumina antacid suspension on the absorption of clorazepate dipotassium was studied in 15 normal healthy adult subjects who ingested a 15‐mg dose of clorazepate alone or with single or multiple doses of antacid. The results of this three‐period randomized complete crossover study showed a trend of initially slower absorption and lower peak nordiazepam plasma levels when administered with the antacid suspension. However, there were no significant differences among treatments in the extent of absorption as measured by the area under the plasma level‐time curves. Clorazepate plasma levels were of relatively short duration and similar for all treatments. The urinary excretion pattern was likewise comparable with conjugated oxazepam, the major species measured. Plasma elimination half‐lives of nordiazepam and clorazepate were not affected by the antacid treatments.