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Effect of pentobarbital on the disposition of alprenolol
Author(s) -
Alvan Gunnar,
Piafsky Kenneth,
Lind Margareta,
von Bahr Christer
Publication year - 1977
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1977223316
Subject(s) - pentobarbital , alprenolol , pharmacokinetics , pharmacology , barbiturate , disposition , medicine , chemistry , anesthesia , propranolol , psychology , social psychology
Alprenolol was administered orally and intravenously to 5 healthy subjects before and after IO to 14 daily doses of 0.1 gm pentobarbital. The area under the plasma concentration time curve after an oral 200‐mg dose decreased from 706 ± 277 to 154 ± 48 ng/ml . hr (mean and SD) with the barbiturate treatment, but there was no significant change in elimination rate. The change in area corresponded to an increase in extraction by the liver from 0.72 ± 0.13 to 0.93 ± 0.01. The disposition ofa 5.0‐mg intravenous dose of alprenolol did not change significantly after pentobarbital treatment. There was no indication of a marked change in hepatic blood flow estimated from the clearance of alprenolol after intravenous administration. It is concluded that pentobarbital administration induces the metabolism ()f alprenolol in man and that the pharmacokinetic theories derived for hepatic extraction of drugs subject to a high metabolic clearance can be successfully applied.