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Kinetics of a sulfadiazine‐trimethoprim combination
Author(s) -
Bergan Tom,
Mo Harald Vik,
Anstad Unni
Publication year - 1977
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1977222211
Subject(s) - sulfadiazine , trimethoprim , renal function , pharmacokinetics , distribution (mathematics) , sulfamethoxazole , chemistry , sulfonamide , pharmacology , urology , medicine , antibiotics , biochemistry , mathematics , stereochemistry , mathematical analysis
The pharmacokinetics of a combination of sulfadiazine and trimethoprim has been studied in 16 patients with varying degrees of reduced renal [unction, In normal renal function, the serum half‐life (t½) of active sulfadiazine, total sulfadiazine, and trimethoprim were quite close: 7.7, 9.6, and 12.1 hr, respectively . There was a gradual increase in serum t½ witlt reduction in renal function for both active and total sulfadiazine andJor trimethoprim. With accurate determinations of endogenous renal clearane, t½ estimates may be made Jrom regression curves presented. The relative distribution in the body was unrelated to renal function. It was similar Jor the two fractions of sulfonamide and higher for trimethoprim. The means were 0.371,0.176, and 1.104 Llkg, respectively, [or active and total sulfudiazine, and trimethoprim.