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Prolongation of gastric emptying by oral propantheline
Author(s) -
Hurwitz Aryeh,
Robinson Ralph G.,
Herrin William F.
Publication year - 1977
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1977222206
Subject(s) - gastric emptying , anticholinergic , medicine , placebo , crossover study , anesthesia , stomach , alternative medicine , pathology
The present study shows that a single oral recommended dose of propantheline bromide normally doubles the mean gastric half‐emptying time in man. In a prospective, double‐blind, randomized crossover design 13 normal subjects were given 30 mg propantheline or placebo 90 min before taking a l l Sm‐indium‐labeled liquid test meal, the volume of which was adjusted to body weight . The disappearance of radioisotope from the area of the stomach was determined by external gamma counting . After placebo the mean half‐emptying time was 68 min and after propantheline it was 135 min (p < 0.005). Although salivary fiow decreased and pulse rate increased there were no visual disturbances . In studies already reported maximally tolerated oral doses of quaternary ammonium anticholinergic drugs have not consistently retarded gastric emptying in man.