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Amelioration of bendrofluazide‐induced hypokalemia by timolol
Author(s) -
Hettiarachchi J.,
Ramsay L. E.,
Davies D. L.,
Fraser R.,
Watson W. S.
Publication year - 1977
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt197722158
Subject(s) - timolol , hypokalemia , potassium , medicine , endocrinology , diuretic , aldosterone , urine , chemistry , pharmacology , surgery , intraocular pressure , organic chemistry
The beta adrenergic blocking drug, timolol, tended to correct the hypokalemia of short‐term bendrofiuazide treatment in 6 healthy male subjects and although the effect was small it was significant. Timolol also reduced the rise in plasma aldosterone and urine potassium excretion following bendrofiuazide and increased the urine sodium/potassium ratio. There was no evidence of a shift of potassium from the intracellular to the extracellular space.