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Diuretic therapies in low renin and normal renin essential hypertension
Author(s) -
Brooks Charles S.,
Johnson Curtis A.,
Kotchen Jane M.,
Kotchen Theodore A.
Publication year - 1977
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt197722114
Subject(s) - hydrochlorothiazide , spironolactone , renin–angiotensin system , medicine , plasma renin activity , diuretic , endocrinology , essential hypertension , blood pressure , mineralocorticoid , urology , pharmacology , aldosterone
This study was designed to compare the effectiveness of spironolactone, hydrochlorothiazide, and combined spironolactone‐hydrochlorothiazide therapy in patients with low renin and those with normal renin essential hypertension. Patients with low renin hypertension had a greater hypotensive response to each regimen (p < 0.001). Low renin patients responded equally to both spironolactone and to hydrochlorothiazide, and in low renin but not in normal renin patients reduction of blood press ure correlated with weight loss. These results suggest that a volume factor, not specifically related to increased mineralocorticoid production, contributes to the pathogenesis of low renin essential hypertension.