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Enhancement by food of canrenone bioavailability from spironolactone
Author(s) -
Melander A.,
Danielson K.,
Seherstén B.,
Thulin T.,
Wåhlin E.
Publication year - 1977
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1977221100
Subject(s) - spironolactone , bioavailability , pharmacology , ingestion , metabolite , active metabolite , oral administration , medicine , chemistry , pharmacokinetics , heart failure
The influence of food intake on the bioavailabiliry of canrenone, the major and active metabolite of spironolactone, was explored in 8 healthy male volunteers. Spironolactone was administered as a single oral dose of 100 mg, both in the fasting state and together wirh a srandardized breakfast. Numerous venous blood sampies were raken from 30 min to 96 hr after ingestion of the drug, and the plasma concentrations of eanrenone were determined by speetrofluorometry. The results indicxate that more eanrenone enters the general circulation when spironolactone is ingested together with a meal.