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Antibiotic‐associated colitis
Author(s) -
Miller Russell R.,
Jick Hershel
Publication year - 1977
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt19772211
Subject(s) - medicine , lincomycin , antibiotics , ampicillin , colitis , drug , microbiology and biotechnology , pharmacology , biology
Among 26,294 hospitalized patients monitored by the Boston Collaborative Drug Surveillance Program (BCDSP), 8,948 (34%) received at least one antibiotic, and none were diagnosed as having drug‐induced colitis due to in‐hospital antibiotic exposure. Seven patients who had taken antibiotics as outpatients, however, were admitted with antibiotic‐associated colitis. Six of these patients had taken lincomycin prior to the onset of symptoms; one had taken ampicillin. Six of the patients were hospitalized at a New Zealand hospital and one at a hospital in Canada. The give patients with lincomycin‐associated colitis at the New Zealand hospital were admitted over an 11‐month period. Severe colitis due to antibiotics has been a rare event in the BCDSP experience, especially in the United States.