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Safety of single large oral doses of guanethidine
Author(s) -
Walter Inge E.,
Nies Alan S.
Publication year - 1977
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1977216706
Subject(s) - guanethidine , inotrope , medicine , heart rate , blood pressure , regimen , anesthesia , cardiology , stimulation
The cardiovascular effects of single 100‐mg doses of guanethidine were assessed in hypertensive patients by measurement of arterial pressure, heart rate, and systolic time intervals. In the 3‐hr period following a dose there was no evidence of an inotropic effect. Therefore, large doses of guanethidine as required for the guanethidine loading regimen would seem to be safe even in patients in whom inotropic effects of released catecholamines would be contraindicated.