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Efficacy and acceptability of different dosage schedules of clonidine
Author(s) -
Jain Adesh K.,
Ryan Jerome R.,
Vargas Ramon,
McMahon F. Gilbert
Publication year - 1977
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1977214382
Subject(s) - clonidine , medicine , bedtime , dosing , blood pressure , regimen , anesthesia , surgery
In 12 hospitalized patients with hypertension, clonidine 3 times a day led to better control of blood pressure than did the same total dose administered once daily. Compared to the uniform control of blood pressure on divided dose regimen, the single daily 8 p.m. dose led to wider fluctuations and inadequate control 18 hr after dosing. However, 10 of the 12 patients preferred the single daily dose at 8:00 p.m. to the divided dose regimen because of no drowsiness during the day. In 2 patients administration of clonidine twice daily resulted in better control of blood pressure than that du ring the single or thrice‐daily dose regimens. Since there appeared to be a correlation between the dose and the duration of adequate blood pressure control, administration of clonidine twice a day with a larger dose at bedtime and a sm aller dose before noon could limit unwanted drowsiness and combine the convenience of less frequent dosing with superior blood pressure control.