Premium
Toward the operational identification of adverse drug reactions
Author(s) -
Karch Fred E.,
Lasagna Louis
Publication year - 1977
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1977213247
Subject(s) - drug , drug reaction , identification (biology) , ambiguity , adverse effect , risk analysis (engineering) , intensive care medicine , medicine , suspect , computer science , pharmacology , psychology , botany , criminology , biology , programming language
The evaluation of adverse drug reactions in clinical practice is somewhat arbitrary and is characterized by considerable differences of opinion. This report presents a decision table algorithm approach toward the development of an operational system for the identification of adverse drug reactions. The algorithm incorporates an estimate of the certainty of the link between the untoward clinical event and the suspect drug, and examines the underlying causes of the identified drug reactions. Use of such a system is a first step toward reducing ambiguity in the evaluation of adverse drug reactions.