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Salivary and urinary lithium clearance while recumbent and upright
Author(s) -
Shimizu Muneo,
Smith Donald F.
Publication year - 1977
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1977212212
Subject(s) - saliva , lithium carbonate , lithium (medication) , urine , excretion , urinary system , medicine , endocrinology , chemistry , ion , organic chemistry , ionic bonding
Excretion of lithium in urine and saliva was studied in healthy males while recumbent and while upright, walking and standing quietly. An oral dose of 24.3 mEq of Li + was taken as three lithium carbonate tablets 13 hr before clearance tests. Urinary lithium clearance decreased when posture was changed from recumbent to upright, but salivary lithium clearance was not affected by the abrupt change in posture. A correlation was observed while recumbent between lithium clearance in urine and saliva, but not while upright. The findings are related to the extrapolation of saliva lithium excretion data to urinary lithium clearance.