Premium
Acetaminophen production in man after coadministration of acetanilid and phenacetin; A study with stable isotopes
Author(s) -
Baty John D.,
Robinson Philip R.
Publication year - 1977
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1977212177
Subject(s) - phenacetin , acetaminophen , metabolite , chemistry , caffeine , hydroxylation , chromatography , metabolism , pharmacology , drug metabolism , biochemistry , enzyme , endocrinology , medicine
A new method for the investigation of interindividual differenees in drug metabolism is described. We have studied the metabolism of ring‐deuterated acetanilid in man following the coadministration of phenaeetin. The principal metabolite of acetanilid‐d 5 is acetaminophen‐d 4 , and the principal metabolite of phenaeetin is acetaminophen‐d 0 . Using agas chromatograph‐mass spectrometer (gc‐ms) we are able to monitor both the deuterium‐labeled acetaminophen produeed by hydroxylation of acetanilid‐d 5 and the nonlabeled material produecd by oxidative removal of the ethyl group in phenacetin. This system allows us to detect differences in the handling of these drugs by different subjects.