Premium
Depression of renal clearance of furosemide in man by azotemia
Author(s) -
Rose H. Josephine,
O'Malley Kevin,
Pruitt Albert W.
Publication year - 1977
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1977212141
Subject(s) - furosemide , azotemia , creatinine , renal function , medicine , urology , bolus (digestion) , endocrinology , chemistry
The renal clearance of furosemide and tetraethylammonium (TEA) were compared in 10 patients with hypertensive nephropathy. BUN and creatinine ranges were 10 to 88 mg/dl and 0.9 to 3.8 mg/dl, respectively. Diuretics were discontinued 48 hr prior to the study, and 2 consecutive clearances (ml/min/1.73 m 2 BSA) of creatinine were performed. The patient then received a bolus followed by a constant infusion of furosemide‐ 14 C and tetraethylammonium‐ 14 C (analyzed by specijic methodology for plasma and urine), both in subpharmacologic doses. After 40‐min equilibration sequential 20‐min clearance periods were obtained. Both the clearance of furosemide (range 17 to 133) and TEA (range 99 to 443) correlated negatively with BUN and serum creatinine and positively with creatinine and urea clearances. Thus, by using a constant‐infusion technique we demonstrated that the renal clearance of furosemide is depressed by azotemia in man and that there was greater depression with furosemide than with TEA.