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Antihypertensive effects of tolamolol
Author(s) -
Vlachakis Nicolas D.,
Mendlowitz Milton,
Krakoff Lawrence R.
Publication year - 1977
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt19772119
Subject(s) - plasma renin activity , blood pressure , medicine , heart rate , ambulatory blood pressure , essential hypertension , diastole , renal function , endocrinology , anesthesia , cardiology , renin–angiotensin system
The antihypertensive and renin‐lowering efficacy and side effects of tolamolol, a beta adrenergic blocking drug with cardioselectivity, were examined in IO patients with mild essential hypertension while on regular diet. Tolamolol, at a dose of 300 to 900 mg per day, given over a period of 2 to 4 wk significantly decreased systolic and diastolic blood pressures in both the recumbent and standing positions. Normal blood pressure (140/90 mm Hg or less) was attained in 8 subjects. Mean heart rate and ambulatory midday plasma renin activity (PRA) decreased significantly; however, there was no significant correlation between blood pressure decrease and either the pretreatment PRA or decrease in PRA. Body weight did not change significantly. No adverse side effects were detected and no changes in the liver or renal function or in the blood count were observed. It is concluded that tolamolol is effective in lowering blood pressure and PRA in patients with hypertension.