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Absorption and metabolism of phenytoin from tablets and capsules
Author(s) -
Smith Thomas C.,
Kinkel Arlyn
Publication year - 1976
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1976206738
Subject(s) - phenytoin , ingestion , metabolite , pharmacology , pharmacokinetics , absorption (acoustics) , chemistry , crossover study , drug , oral administration , urinary system , plasma concentration , urine , chromatography , medicine , biochemistry , epilepsy , materials science , alternative medicine , composite material , pathology , psychiatry , placebo
Crossover studies were conducted to compare plasma levels of phenytoin and urinary throughput of the major metabolite, 5‐(p‐hydroxyphenyl)‐5‐phenylhydantoin (HPPH), after ingestion of single 250‐mg oral doses as tablets or as capsules. Plasma levels of phenytoin did not differ significantly for the 2 formulations except at 8 and 12 hr after ingestion of drug, when the mean values for the tablets were higher than for the capsules. The normalized area under the curve, however, did not differ significantly for either preparation, indicating that equivalent amounts of each preparation were absorbed. Urinary throughput of HPPH did not differ significantly between the 2 preparations. The results suggest that the 2 preparations provide equivalent therapeutic efFects.