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Correlation between electrocardiographic changes, serum digoxin, and total body digoxin content
Author(s) -
Joubert Pieter,
Kroening Bruce,
Weintraub Michael,
Fleckenstein Lawrence
Publication year - 1976
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1976206676
Subject(s) - digoxin , medicine , linear correlation , linear relationship , correlation , pr interval , anesthesia , cardiology , endocrinology , heart rate , mathematics , heart failure , statistics , blood pressure , geometry
Serial electrocardiograms and serum digoxin levels were obtained in four healthy volunteers receiving daily doses of digoxin, 0.25 mg for the first two weeks and 0.5 mg for two more weeks. We found a linear relationship between serum digoxin levels and the “PTQ index” (a function of the PR‐interval, corrected QT‐time, and T‐wave depression). In 3 of the 4 subjects the correlation was statistically significant. The degree of linear correlation was improved when PTQ was correlated with the computer‐calculated total body burden of digoxin.