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Aminopyrine disposition: Studies on breath, saliva, and urine of normal subjects and patients with liver disease
Author(s) -
Hepner Gershon W.,
Vesell Elliot S.
Publication year - 1976
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1976206654
Subject(s) - breath test , urine , saliva , disposition , gastroenterology , medicine , oral administration , chemistry , psychology , social psychology , helicobacter pylori
To investigate aminopyrine disposition, breath, saliva, and urine were collected from 25 control patients, 15 patients with hepatocellular disease, and 26 patients with hepatic neoplasm after oral administration of 2 µCi [ 14 C]aminopyrine. The percentage 14 C excreted in breath 14 CO 2 in 2 hr (aminopyrine breath test, ABT) correlated with the breath 14 CO 2 elimination rate (r = 0.92, p < 0.01), with the aminopyrine metabolic clearance rate (MCR) (r = 0.85, p < 0.01), and with the plasma half‐life of 4‐aminoantipyrine (r = −0.54, p < 0.05). The ABT permits study of aminopyrine disposition with simplicity, accuracy, and safety.