Systemic availability of orally administered meperidine | Zendy

Mather L. E. | Zendy; Tucker G. T. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Systemic availability of orally administered meperidine

Author(s) -

Mather L. E.,

Tucker G. T.

Publication year - 1976

Publication title -

clinical pharmacology and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.941

H-Index - 188

eISSN - 1532-6535

pISSN - 0009-9236

DOI - 10.1002/cpt1976205535

Subject(s) - oral administration , drug , pharmacology , pharmacokinetics , plasma concentration , absorption (acoustics) , first pass effect , oral dose , medicine , drug administration , anesthesia , physics , acoustics

A comparison of the areas under the plasma concentration‐time curves after intravenous and oral administration of meperidine in 4 normal subjects indicated that 48% to 56% of the oral dose avoided “first‐pass” metabolism and was systemically available. Similar estimates were obtained by applying the Loo‐Riegelman method for calculating drug absorption viz, 47% to 60%. Oral availability predicted from a knowledge of drug clearance (blood) after intravenous injection was 47% to 71%. In some subjects plasma drug concentration‐time curves after oral administration exhibited irregularities and double peaks possibly indicative of the action of meperidine on the gut or a recycling process.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research