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Systemic availability of orally administered meperidine
Author(s) -
Mather L. E.,
Tucker G. T.
Publication year - 1976
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1976205535
Subject(s) - oral administration , drug , pharmacology , pharmacokinetics , plasma concentration , absorption (acoustics) , first pass effect , oral dose , medicine , drug administration , anesthesia , physics , acoustics
A comparison of the areas under the plasma concentration‐time curves after intravenous and oral administration of meperidine in 4 normal subjects indicated that 48% to 56% of the oral dose avoided “first‐pass” metabolism and was systemically available. Similar estimates were obtained by applying the Loo‐Riegelman method for calculating drug absorption viz, 47% to 60%. Oral availability predicted from a knowledge of drug clearance (blood) after intravenous injection was 47% to 71%. In some subjects plasma drug concentration‐time curves after oral administration exhibited irregularities and double peaks possibly indicative of the action of meperidine on the gut or a recycling process.