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Protein binding of salicylate in uremic and normal plasma
Author(s) -
Borgå Olof,
OdarCederlöf Ingegerd,
Ringberger ViviAnn,
Norlin Allan
Publication year - 1976
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1976204464
Subject(s) - chemistry , plasma protein binding , uremia , albumin , dialysis , binding site , blood proteins , medicine , sodium salicylate , plasma levels , endocrinology , pharmacology , biochemistry , organic chemistry
Protein binding of salicylate was studied by equilibrium dialysis at 37° C in plasma from uremic patients and healthy subjects. The protein binding was considerably lower in the uremic plasma at all salicylate concentrations studied (14 to 1,400 μg/ml). Scatchard plots of the data were computer‐analyzed assuming binding to two classes of binding sites. According to this analysis, the binding to the class of primary binding sites was considerably decreased in the uremic plasma. In addition to the effect of the uremic state, the binding was considerably decreased at high therapeutic plasma levels and at low albumin levels. The combined effect of two or three of these factors may lead to unexpectedly high unbound fractions of salicylate, which should be considered in the monitoring of plasma salicylate levels in patients.