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Bumetanide, a new loop diuretic
Author(s) -
Carrière S.,
Dandavino R.,
Rochefort F.,
Daigneault A.,
Lanoix C.
Publication year - 1976
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1976204424
Subject(s) - bumetanide , diuretic , loop diuretic , loop (graph theory) , pharmacology , chemistry , medicine , mathematics , cotransporter , sodium , organic chemistry , combinatorics
The effect of bumetanide on renal function has been compared with that o.ffurosemide and a placebo in a double‐blind study in 9 healthy young men. The sequence for oral administration of the drug was subjected to a random assignation based upon the Latin‐square methodology under three different conditions. (I) Normal hydration: The administration of bumetanide (2 mg) produced within the next 4 hr a diuresis comparable to that induced by 80 mg offurosemide. Urinary excretion of sodium, potassium, chloride, calcium, and uric acid also followed comparable patterns. Phosphaturia occurred only under bumetanide. The effect of bumetanide seemed longer lasting. (2) Water loading: The e.ffects o.f bumetanide andfurosemide were comparable with the exception of the phosphaturic effect induced by bumetanide. The action of both diuretics on the diluting segment of the nephron was well demonstrated by the marked depression of CH 2 O. (3) Water deprivation: The effects o.f the two diuretics were comparable, including depression of T CH 2 O. In none of these conditions did the placebo produce any significant effect.