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Paradoxical urinary excretion of o‐glucaric acid in acute viral hepatitis
Author(s) -
Sorrell Michael F.,
Burnett David A.,
Tuma Dean J,,
Barak Anthony J.
Publication year - 1976
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1976203365
Subject(s) - excretion , viral hepatitis , urinary system , medicine , gastroenterology , virology
The urinary excretioll of D‐glucaric acid alld the plasma clearance of antipyrine were estimated dllring the acute phase of viral hepatitis and agaill during recovery. The plasma c1earallce of antiprrille was impaired durillg the acute stage of hepatitis, while the IIrillarr excretioll of D‐gilicaric acid was paradoxically high. Both parameters returned to Ilormal dllring recovery. These filldings suggest that the lise of urinary D‐glucaric acid excretion as an illdex of microsomal ellzyme induction is unreliable whell there is liver injury.