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Influence of viral hepatitis on the disposition of two compounds with high hepatic clearance: Lidocaine and indocyanine green
Author(s) -
Williams Roger L.,
Blaschke Terrence F.,
Meffin Peter J.,
Melmon Kenneth L.,
Rowland Malcolm
Publication year - 1976
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1976203290
Subject(s) - indocyanine green , lidocaine , pharmacokinetics , volume of distribution , disposition , medicine , clearance , hepatitis , liver disease , pharmacology , anesthesia , urology , pathology , psychology , social psychology
The disposition of lidocaine and indocyanine green was studied in 6 individuals during and after recovery from an episode of acute viral hepatitis. Both compounds are highly cleared from the blood by the liver so that clearance of both should be sensitive to changes in hepatic blood flow. During the acute phase of illness, clearance of indocyanine green decreased without apparent change in volume of distribution, whereas clearance of lidocaine, decreased in 4, did not change in I, and increased in 1 during the acute phase of hepatitis. Volume changes for lidocaine were also variable. We observed no significant correlation between any parameters of lidocaine disposition and any of several tests of liver function or any parameters of indocyanine green disposition. The absence of correlation between pharmacokinetic parameters of the disposition of lidocaine and indocyanine green indicates that the influence of hepatic disease on the hepatic processes that lead to the elimination of each compound is not predictable. No useful clinical correlates are now available by means of which to predict lidocaine disposition in patients with altered hepatic function.