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Pharmacokinetics of naproxen overdoses
Author(s) -
Runkel Richard,
Chaplin Melvin D.,
Sevelius Hilli,
Ortega Eduardo,
Segre Eugene
Publication year - 1976
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1976203269
Subject(s) - naproxen , pharmacokinetics , rheumatoid arthritis , medicine , adverse effect , pharmacology , drug , urine , excretion , metabolic clearance rate , alternative medicine , pathology
In earlier safety studies, naproxen, 600 mg three times daily, was administered to healthy subjects without significant adverse effects. Another study demonstrated that single doses of 500 to 900 mg resulted in accelerated renal clearance and a nonlinear naproxen plasma level response after the higher doses. Our report describes the pharmacokinetics of naproxen when administered in single doses of J, 2, 3, or 4 gm (up to eight times the clinically e.ffective dose in rheumatoid arthritis) to healthy subjects. An increase in urinary excretion rate and continuation of the previously documented nonlinear plasma level response were observed. There were no signs that capacity to conjugate or to excrete the drug was exceeded. There were no adverse effects.