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Transient cardiac arrhythmias after single daily maintenance doses of digoxin
Author(s) -
Manninen V.,
Reissell P.,
Paukkala E.
Publication year - 1976
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1976203266
Subject(s) - digoxin , medicine , cardiology , serum concentration , anesthesia , heart failure
Ten digitalized patients were monitored for detection of cardiac arrhythmias 0 to 8 hr after daily maintenance dose of digoxin in the fasting state. Transient cardiac arrhythmias attributable to digoxin were seen at 2 to 5 hr in 5 subjects. Initial serum concentrations of digoxin were within standard clinical limits in all subjects, but, higher steady‐state levels were present in patients with arrhythmias (1.2 to 1.7 nglml) than in the others (0.7 to 1.2 nglml). The postadministrative serum peak concentrations were also higher in the patients with arrhythmias.