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Absolute quinidine bioavailability
Author(s) -
Ueda Clarence T.,
Williamson Blake J.,
Dzindzio Barry S.
Publication year - 1976
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1976203260
Subject(s) - quinidine , bioavailability , pharmacology , medicine , chemistry
The absolute bioamilability of quinidine was studied in II hospitalized patients. A 400‐mg dose of quinidine gluconate was administered to each patient In intravenous infusion and as an oral solution. Drug treatments were separated by a 72‐hr period. In 8 patients. peak plasma quinidine concentrations were reached in 65 min after the oral dose; in the remaining 3 subjects. peak concentrations were reached later. From the ratio of the roral area under the plasma concenfration‐time curves (AUC oral AUC ir ). the absolute bioamilability of quinidine rangedfrom 44% to 89%, (mean. 72). In 8 patients. the ratio of the total amount of quinidine excreted in the urine in 48 hr (Au oral /Au ir ) indicated that the extent of quinidine biovailability varied from 47% to 96% (mean. 73). The predicted biovailability of quinidine due to first‐pass effects was 76 = 11%. It is concluded that absorption atter the oral solution was rapid and that the reduction of quinidine bioavailability was due to first‐pass hepatic drug revoral.