Intestinal blood loss after a new anti‐inflammatory drug, sulindac

Sulindac was tested for fecal blood loss in 40 healthy male subjects whose red cells had been labeled with Na 2 51 CrO 4 . Two daily dose levels of 240 mg and 400 mg were compared with 4.8 gm of aspirin and placebofor 2 wk. At day 15, aspirin‐induced blood loss was greater than that of both dose levels of sulindac and of placebo (p < 0.05). There were no significant differences between the two sulindac groups and the placebo group. Aspirin caused more adverse reactions than sulindac, 240 mg (p < 0.05), 400 mg (p < 0.05), and placebo (p < 0.05).