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Intestinal blood loss after a new anti‐inflammatory drug, sulindac
Author(s) -
Cohen Albert
Publication year - 1976
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1976202238
Subject(s) - sulindac , drug , medicine , pharmacology , nonsteroidal
Sulindac was tested for fecal blood loss in 40 healthy male subjects whose red cells had been labeled with Na 2 51 CrO 4 . Two daily dose levels of 240 mg and 400 mg were compared with 4.8 gm of aspirin and placebofor 2 wk. At day 15, aspirin‐induced blood loss was greater than that of both dose levels of sulindac and of placebo (p < 0.05). There were no significant differences between the two sulindac groups and the placebo group. Aspirin caused more adverse reactions than sulindac, 240 mg (p < 0.05), 400 mg (p < 0.05), and placebo (p < 0.05).