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Enzyme induction by oral testosterone
Author(s) -
Johnsen Svend G.,
Kampmann Jens P.,
Bennett Edgar P.,
Jørgensen F. Schønau
Publication year - 1976
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1976202233
Subject(s) - testosterone (patch) , alkaline phosphatase , medicine , ingestion , endocrinology , bilirubin , prothrombin time , albumin , enzyme inducer , enzyme , chemistry , biochemistry
Six normal male volunteers ingested a dose of 400 mg free testosterone daily as tablets over 21 days. By the end of treatment intravenous antipyrine half‐life had decreased significantly from 8.0 ± 2.7 to 5.7 ± 2.6 hr. The subjects eliminated testosterone from serum more rapidly on the twenty‐first day of testosterone ingestion than on the first day. Serum albumin, bilirubin, prothrombin, alanine‐amino‐transferase, and alkaline phosphatases were unchanged during the experiment. It is concluded that oral testosterone treatment induces the hepatic drug‐metabolizing system including that of testosterone.