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Metabolism of ethosuximide
Author(s) -
Goulet J. R.,
Kinkel A. W.,
Smith T. C.
Publication year - 1976
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1976202213
Subject(s) - ethosuximide , regimen , medicine , pharmacokinetics , urine , pharmacology , anticonvulsant , psychiatry , epilepsy
Twenty subjects, in a double‐blind, controlled, rising dose study, were given ethosuximide either once daily or 3 times daily. Steady‐state plasma levels and urinary throughput were proportional to dose and were equivalent whether the daily dose was given as a single or a divided dose. This finding adds validity to consideration of the single daily dose regimen as a therapeutic possibility. The metabolic principles should be considered both in patient management and in the treatment of overdosage.