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Effect of diazepam on ventilatory responses
Author(s) -
Lakshminarayan S.,
Sahn Steven A.,
Hudson Leonard D.,
Weil John V.
Publication year - 1976
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1976202178
Subject(s) - diazepam , anesthesia , medicine , hypoxemia , depression (economics) , hypoxic ventilatory response , ventilation (architecture) , respiration , respiratory system , mechanical engineering , anatomy , engineering , economics , macroeconomics
To investigate the effects of diazepam on ventilatory control, hypoxic and hypercapnic ventilatory responses were studied in 8 normal subjects before and after 10 mg of intramuscular diazepam. There was no significant change in either resting minute ventilation or resting end‐tidal CO2 tension, but depression of hypoxic ventilatory response was observed 15 (60% of control) and 30 min (53% of control) after diazepam (p < 0.05). No significant depression of hypercapnic ventilatory response was noted 70 to 130 min alter diazepam. In view of the depression of hypoxic ventilatory response by diazepam in normal subjects, adverse responses along these lines should be considered in patients with impaired ventilatory function, such as chronic airways obstruction, and in those encountering acute hypoxemia.