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Antihypertensive effects of oxprenolol and propranolol
Author(s) -
Materson Barry J.,
Michael Ulrich F.,
Oster James R.,
PerezStable Eliseo C.,
Hernandez Alba,
Smith Mary
Publication year - 1976
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1976202142
Subject(s) - oxprenolol , propranolol , pharmacology , medicine , anesthesia
The antihypertensive effects of the beta blockers oxprenolol and propranolol were compared in a randomized double‐blind study of patients with standing diastolic pressures (SDP) exceeding 99 mm Hg when receiving hydrochlorothiazide alone. After 3 wk of hydrochlorothiazide with placebo, the latter was replaced with oxprenolol (n = 12) or propranolol (n = 12), 20 mg three times daily. Beta blocker was increased subsequently to 40 and 80 mg three times daily if SDP exceeded 89 mm Hg. Nine oxprenolol and 7 propranolol subjects were hospitalized for 24‐hr monitoring. With oxprenolol, standing pressure declined from 135 ± 2 (S£)/104 ± 1 mm Hg to 128 ± 3/90 ± 2. SDP declined to under 91 mm Hg in 7 of 12 subjects, and to from 91 to 95 in 3 subjects. With propranolol, findings were 138 ± 3/106 ± 2 to 123 ± 3/89 ± 3; in 7 of 12 to less than 91 mm Hg and from 91 to 95 in 4 subjects. Decrements in supine and SDP were slightly (4 mm Hg) greater for propranolol than for oxprenolol. Both drugs gave similar 24‐hr blood pressure control. We conclude that oxprenolol and propranolol used to supplement hydrochlorothiazide provide comparable reductions in blood pressure and smooth control over a 24‐hr period in most patients with hypertension.