Elimination of antipyrine and benzo[a]pyrene metabolism in cultured human lymphocytes | Zendy

Kellermann Gottfried | Zendy; LuytenKellermann Mieke | Zendy; Horning Marjorie G. | Zendy; Stafford Michele | Zendy

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Elimination of antipyrine and benzo[a]pyrene metabolism in cultured human lymphocytes

Author(s) -

Kellermann Gottfried,

LuytenKellermann Mieke,

Horning Marjorie G.,

Stafford Michele

Publication year - 1976

Publication title -

clinical pharmacology and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.941

H-Index - 188

eISSN - 1532-6535

pISSN - 0009-9236

DOI - 10.1002/cpt197620172

Subject(s) - pyrene , chemistry , benzo(a)pyrene , metabolism , population , aryl , methylcholanthrene , carcinogen , stereochemistry , biochemistry , organic chemistry , medicine , alkyl , environmental health

A strong correlation was found in a carefully selected homogenous population (n = 57) between antipyrine plasma half‐life and the percent induction of aryl hydrocarbon hydroxylase by 3‐methylcholanthrene in mitogen‐stimulated lymphocytes from the same individual. The correlation coefficient of r = −0.923 indicates that antipyrine and benzo[a]pyrene share one or several common determinants that are responsible for the observed interindividual variation in the oxidation rates of the two compounds. When a heterogenous population (n = 80) was studied. the above correlation was not found (r = −0.425).

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