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Elimination of antipyrine and benzo[a]pyrene metabolism in cultured human lymphocytes
Author(s) -
Kellermann Gottfried,
LuytenKellermann Mieke,
Horning Marjorie G.,
Stafford Michele
Publication year - 1976
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt197620172
Subject(s) - pyrene , chemistry , benzo(a)pyrene , metabolism , population , aryl , methylcholanthrene , carcinogen , stereochemistry , biochemistry , organic chemistry , medicine , alkyl , environmental health
A strong correlation was found in a carefully selected homogenous population (n = 57) between antipyrine plasma half‐life and the percent induction of aryl hydrocarbon hydroxylase by 3‐methylcholanthrene in mitogen‐stimulated lymphocytes from the same individual. The correlation coefficient of r = −0.923 indicates that antipyrine and benzo[a]pyrene share one or several common determinants that are responsible for the observed interindividual variation in the oxidation rates of the two compounds. When a heterogenous population (n = 80) was studied. the above correlation was not found (r = −0.425).