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A sliding intravenous dose schedule for clonidine in hypertensive patients
Author(s) -
Velasco Manuel,
Gallardo Edilio,
Plaja Joaquin,
Guevara José
Publication year - 1976
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt197620131
Subject(s) - clonidine , blood pressure , medicine , anesthesia , heart rate , mean arterial pressure , potency , mean blood pressure , chemistry , biochemistry , in vitro
Cumulative doses of clonidine were administered intravenously to 8 hypertensive patients to a maximal dose of 100 μg or a blood pressure fall to normal. There was a reduction in mean arterial pressure of 35.6 mm Hg (p < 0.001), accompanied by a decrease in heart rate of 11.8 bpm (p < 0.001). There was also a significant linear relationship between the reduction in blood pressure and the intravenous log dose of clonidine with a 6.5‐fold difference in Δ MAP/dose potency. There was no correlation between the baseline blood pressure and the slopes of dose‐blood pressure response curves or the reduction in mean arterial pressure; the rate of the decline of the hypotensive effect of clonidine varied widely between patients and was not related to baseline blood pressure.