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Correspondence; Renal elimination of procainamide
Author(s) -
Koch-Weser Jan
Publication year - 1976
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1976196830
Subject(s) - procainamide , renal function , urology , chemistry , creatinine , urinary system , medicine , endocrinology , pharmacology
The artic1e by Galeazzi and co‐workers on renal elimination of procainamide 1 is summarized in the table of contents as showing “that the tubular secretion of procainamide is its major route of renal elimination and that glomerular filtration rate, passive absorption, and urinary pH are not of c1inical significance.” This summary is at variance with the results, discussion, and summary of the authors, who conclude that passive tubular diffusion of procainamide is relatively unimportant, but recognize the importance of its filtration through glomeruli. Glomerular filtration is a major and at high serum concentrations may be the predominant mechanism for the renal elimination of procainamide. 2‐5 The good correlation between renal clearances of creatinine and procainamide makes the former clinically useful in the individualization of procainamide dosage. 4