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Intestinal absorption, demethylation, and enterohepatic circulation of imipramine
Author(s) -
Dencker Hans,
Dencker Sven Jonas,
Green Anders,
Nagy Adam
Publication year - 1976
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1976195part1584
Subject(s) - enterohepatic circulation , demethylation , desipramine , imipramine , absorption (acoustics) , pharmacology , chemistry , pharmacokinetics , metabolism , medicine , endocrinology , biochemistry , pathology , gene expression , alternative medicine , physics , antidepressant , hippocampus , acoustics , dna methylation , gene
The intestinal absorption and metabolism of single oral doses of imipramine (ip) have been studied in man by portal catheterization. The concentration of ip and the formed desipramine (dmi) was followed in blood‐plasma obtained from the portal and cubital veins. The absorption of ip seemed to be completed 80 min after the administration of the drug. There was no sign of demethylation of ip during the passage across the intestinal wall. Evidence was found of an enterohepatic circulation of both ip and dmi.