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Propoxyphene and norpropoxyphene: Influence of diet and fluid on plasma levels
Author(s) -
Welling P. G.,
Lyons L. L.,
Craig W. A.
Publication year - 1976
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1976195part1559
Subject(s) - propoxyphene , bioavailability , metabolite , pharmacokinetics , pharmacology , absorption (acoustics) , drug , chemistry , absorption efficiency , plasma concentration , dosing , active metabolite , medicine , analgesic , zoology , biology , physics , acoustics
The influence of various test meals and ingested fluid volumes on the bioavailability and pharmacokinetics of propoxyphene and its major metabolite norporpoxyphene has been studied in healthy human subjects. The absorption of drug was delayed by all test meals, but the overall efficiency of absorption was either not affected or was slightly increased. Increased fluid volume intake decreased propoxyphene bioavailability. Plasma levels of metabolite correlated well with levels of unchanged drug, particularly in the first 2 hr after dosing, but were not markedly influenced by treatments.