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The effect of arterial oxygen tension on antipyrine half‐time in plasma
Author(s) -
Cumming James F.
Publication year - 1976
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1976194468
Subject(s) - arterial oxygen tension , oxygen , medicine , oxygen tension , plasma concentration , arterial blood , anesthesia , cardiology , chemistry , lung , organic chemistry
Hospital patients with depressed arterial oxygen tensions (PaO 2 ) from pulmonary disease were given antipyrine orally or intravenously. The half‐time (t ½ ) of disappearance from plasma was measured. Other patients with normal Pa02 measurements were treated similarly. Patients whose PaO 2 was 55 or below had longer t ½ times than those of patients with a PaO 2 above 55. This observation parallels that made previously in rats.