Premium
The effect of arterial oxygen tension on antipyrine half‐time in plasma
Author(s) -
Cumming James F.
Publication year - 1976
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1976194468
Subject(s) - arterial oxygen tension , oxygen , medicine , oxygen tension , plasma concentration , arterial blood , anesthesia , cardiology , chemistry , lung , organic chemistry
Hospital patients with depressed arterial oxygen tensions (PaO 2 ) from pulmonary disease were given antipyrine orally or intravenously. The half‐time (t ½ ) of disappearance from plasma was measured. Other patients with normal Pa02 measurements were treated similarly. Patients whose PaO 2 was 55 or below had longer t ½ times than those of patients with a PaO 2 above 55. This observation parallels that made previously in rats.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom