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Antitussive activity of diphenhydramine in chronic cough
Author(s) -
Lilienfield Lawrence S.,
Rose John C.,
Princiotto Joseph V.
Publication year - 1976
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1976194421
Subject(s) - diphenhydramine , medicine , placebo , chronic bronchitis , anesthesia , crossover study , bronchitis , incidence (geometry) , pharmacology , histamine , alternative medicine , optics , physics , pathology
A double‐blind crossover study was conducted to evaluate the antitussive effectiveness of diphenhydramine (DPH) in chronic coughs related to bronchitis, at doses of25 and 50 mg every 4 hr for four doses. Both 25− and 50‐mg doses caused a statistically and clinically significant reduction in frequency of coughs, compared to placebo. The most frequently reported side effect was drowsiness, principally at the 50‐mg dose level. There was little or no apparent correlation between antitussive effectiveness and incidence of drowsiness, however, suggesting that the two effects were pharmacologically unrelated.