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Acebutolol: Basis for the prediction of effect on exercise tolerance
Author(s) -
Biron Pierre,
Tremblay Gerard
Publication year - 1976
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1976193333
Subject(s) - acebutolol , heart rate , rate pressure product , medicine , placebo , treadmill , blood pressure , angina , repeated measures design , cardiology , analysis of variance , anesthesia , mathematics , myocardial infarction , statistics , alternative medicine , pathology
Twelve unselected males suffering from documented coronary insufficiency and moderately severe angina were submitted to graded multistage treadmill exercise testing on 3 separate days, 3.5 hr after a single dose of 0, 200, or 400 mg of acebutolol, a cardioselective beta blocker. Control measures included random allocation of 2 patients to each of 6 balanced sequences of administration, standardized double‐blind conditions, and variance analysis for Latin‐square design with repeated measures on each subject. Performance was evaluated by measuring time elapsed until anginal pain, peak heart rate, peak product of heart rate and blood pressure, and peak oxygen consumption. Mean values for all criteria were significantly altered by 400 mg of acebutolol. Seven out of twelve patients were classified as responders (i.e., exercise duration increased 100% or more). The response after acebutolol was correlated with the performance on placebo in the case of exercise duration, peak heart rate, and peak product of heart rate and blood pressure. It is concluded that: (1) performance criteria are useful predictors of response to beta blockade and (2) acebutolol is a potent antianginal agent when judged by an objective treadmill exercise test.